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Structural Bioinformatics in Cancer Drug Discovery and Post-Genomics Studies
Speaker:
Dr. Hua Jing
Department of Biochemistry and Molecular Biology, University of Texas
Time: 10-11am, Wednesday June 20
Location: Room 610, New Life Science Building, Peking University
Abstract:
Structural bioinformatics is an integration of structural biology and bioinformatics.
One of the major aspects of structural bioinformatics is the integrative analysis of
protein sequence, structure, and function. I will illustrate how such an integrative
analysis can be useful in cancer drug discovery and post-genomics studies, in
addition to classical biological studies. I will demonstrate 1) strategies in
rational design of domain constructs for structural and functional studies, 2)
analyses of kinases to understand the effects of cancer-related mutations, and 3)
discovery of novel ????propeller domains in protein sequences. I will conclude the
seminar with a speculation on what can be done in structural bioinformatics in the
near future and how can biomedical researchers use powerful informatics tools to
advance their own research projects.
About the speaker:
Hua Jing received the PhD degree from Center for Macromolecular Crystallography at
the University of Alabama at Birmingham, Birmingham in 1998, and then she worked as a
postdoctoral fellow at Harvard Medical School in 1999 - 2002 and a scientist at
AstraZeneca Pharmaceutical Inc. In 2006, she joined The University of Texas as an
assistant professor, in Department of Biochemistry and Molecular Biology. Her main
research interests include studying the structure and function of human proteins that
have been shown to be important in diseases and bioinformatics analysis of human proteins
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