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Glycan structure determination using MS/MS
Speaker:
Prof. Bin Ma
Department of Computer Science
iUniversity of Western Ontario
Time: 2-3pm, Wednesday Nov. 22
Location: Room 610, New Life Science Building, Peking University
Abstract:
Glycosylation is the most common and one of the most important
post-translation modifications of proteins. While peptide sequences
are being sequenced by MS/MS routinely, the structures of glycans
are very hard to determine. The difficulty is particularly because
the glycan has a tree structure, which is more complex than a sequence
structure. The manual interpretation of the MS/MS spectrum of
a glycopeptide is very time consuming and require very experienced
personnel. In the talk we will formulate the interpretation as a computational
problem, introduce the computational complexity and heuristic algorithms
to the problem.
Bio:
Bin Ma is a Canada Research Chair and an associate professor in
Department of Computer Science at University of Western Ontario.
He received his Ph.D. degree from Beijing University in 1999. He is
currently on his sabbatical leave at Tsinghua University.
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